Greener BeeGreen LivingWhat a Single Fatty Meal Can Do To Our Arteries

The phenomenon of postprandial angina was described more than 200 years ago: chest pain that occurs after a meal, even if you’re just sitting down and resting. This could be intuitively attributed to redistribution of blood flow away from the heart to the gut during digestion. However, such a mechanism could not be demonstrated experimentally.

The problem appears to be within the coronary arteries themselves. The clue came in 1955 when researchers found they could induce angina in people with heart disease just by having them drink fat. My video below includes a fascinating graph of so-called lactescence, or milkiness, over time. It shows how their blood became increasingly milky with fat over the next five hours, and each of the ten attacks of angina was found to occur about four-and-a-half to five hours after the fatty meal, right when blood milkiness was at or near its peak. After a nonfat meal with the same bulk and calories, but made out of starch, sugar and protein, no anginal pain was elicited in any of the patients.

To understand how the mere presence of fat in the blood can affect blood flow to the heart, we need to understand the endothelium, the inner lining of all of our blood vessels. Our arteries are not just rigid pipes; they are living, breathing organs that actively dilate or constrict, thinning or thickening the blood and releasing hormones, depending on what’s needed. This is all controlled by the single inner layer, the endothelium, which makes it the body’s largest endocrine (hormone-secreting) organ. When it’s all gathered up, the endothelium weighs a total of three pounds and has a combined surface area of 700 square yards.

We used to think the endothelium was just an inert layer lining our vascular tree, but now we know better:

The endothelium is directly involved in peripheral vascular disease, stroke, heart disease, diabetes, insulin resistance, chronic kidney failure, tumor growth, metastasis, venous thrombosis [blood clots] and severe viral infectious diseases. Dysfunction of the vascular endothelium is thus a hallmark of human diseases.

Researchers found that low-fat meals tend to improve endothelial function, whereas high-fat meals tend to worsen it. This goes for animal fat, as well as isolated plant fats, such as sunflower oil. But, maybe it’s just the digestion of fat rather than the fat itself? Our body can detect the presence of fat in the digestive tract and release a special group of hormones and enzymes. Researchers tried feeding people fake fat and found that the real fat deprived the heart of blood while the fake fat didn’t. Is our body really smart enough to tell the difference?

A follow-up study settled the issue. Researchers tried infusing fat directly into people’s bloodstream through an IV to sneak it past your mouth and brain. Within hours, their arteries stiffened, significantly crippling their ability to relax and dilate normally. So it was the fat after all! This decrease in the ability to vasodilate coronary arteries after a fatty meal, just when you need it, could explain the phenomenon of after-meal angina in patients with known coronary artery disease.

In health,
Michael Greger, M.D.

PS: If you haven’t yet, you can subscribe to my free videos here and watch my live, year-in-review presentations—2015: Food as Medicine: Preventing and Treating the Most Dreaded Diseases with Diet, and my latest, 2016: How Not To Die: The Role of Diet in Preventing, Arresting, and Reversing Our Top 15 Killers.

Related
Dark Chocolate and Artery Function
Turmeric Curcumin vs. Exercise for Artery Function
Coffee and Artery Function

Article source: http://www.care2.com/greenliving/what-a-single-fatty-meal-can-do-to-our-arteries.html


Comments

What a Single Fatty Meal Can Do To Our Arteries — No Comments

Leave a Reply

Your email address will not be published. Required fields are marked *